3 : One Danger After Another: Degeneration
The only way to confirm a diagnosis of CJD is by brain biopsy or an autopsy. In a brain biopsy, a neurosurgeon removes a small piece of tissue from the living person's brain so it can be examined by a neuropathologist. This procedure may be dangerous for the individual and is generally discouraged unless it is needed to rule out a treatable disorder. In an autopsy, the whole brain is examined after death.
3 : One Danger After Another: Degeneration
Tendons are particularly prone to degeneration and injury after a cortisone injection. Because of this risk, a doctor will not inject cortisone medication directly into a tendon, even if a tendon is suspected to be the root of the pain. Because cortisone works locally, an injected placed near a tendon can still reduce its inflammation.
TENAYA (NCT03823287) and LUCERNE (NCT03823300) are two identical, randomized, multicenter, double-masked, global Phase III studies evaluating the efficacy and safety of Vabysmo compared to aflibercept in 1,329 people living with wet age-related macular degeneration (671 in TENAYA and 658 in LUCERNE). The studies each have two treatment arms: Vabysmo 6.0 mg administered at intervals of two, three, or four months, following four initial monthly doses, selected based on objective assessment of disease activity as measured by optical coherence tomography and visual acuity evaluations at weeks 20 and 24; and aflibercept 2.0 mg administered at fixed two-month intervals after three initial monthly doses. In both arms, sham injections were administered at study visits when treatment injections were not scheduled, to maintain the masking of investigators and participants. 041b061a72